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Literature summary for 2.4.1.17 extracted from

  • Matern, H.; Matern, S.; Gerok, W.
    Isolation and characterization of rat liver microsomal UDP-glucuronosyltransferase activity toward chenodeoxycholic acid and testosterone as a single form of enzyme (1982), J. Biol. Chem., 257, 7422-7429.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
UDP-N-acetylglucosamine inhibition or chenodeoxycholic acid and testosterone glucuronidation Rattus norvegicus
UDPgalactose inhibition or chenodeoxycholic acid and testosterone glucuronidation Rattus norvegicus
UDPgalacturonic acid inhibition or chenodeoxycholic acid and testosterone glucuronidation Rattus norvegicus
UDPxylose inhibition or chenodeoxycholic acid and testosterone glucuronidation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
316000 318000 gel filtration, polyacrylamide gradient slab gel electrophoresis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley rat
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein no glycoprotein Rattus norvegicus
phospholipoprotein less than 3 mol phospholipid per mol of enzyme Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside sequential bireactant mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.168
-
chenodeoxycholic acid, Sprague-Dawley rat treated with phenobarbital Rattus norvegicus
0.983
-
testosterone, Sprague-Dawley rat treated with phenobarbital Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, at least 1 month Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chenodeoxycholic acid + UDP-glucuronate
-
Rattus norvegicus UDP + ?
-
?
chenodeoxycholic acid + UDPgalacturonate
-
Rattus norvegicus UDP + chenodeoxycholic acid O-galacturonide
-
?
testosterone + UDPglucuronate UDPglucuronate can be substituted by UDPgalacturonate yielding 83-88% of the activity Rattus norvegicus UDP + testosterone O-glucuronide
-
?

Subunits

Subunits Comment Organism
? additional values for rat isozymes ranging from 51000 to 59000 Rattus norvegicus
? all values determined by SDS-PAGE Rattus norvegicus