Literature summary for 2.4.1.17 extracted from

Said, M.; Noort, D.; Magdalou, J.; Ziegler, J.C.; van der Marel, G.A.; van Boom, J.H.; Mulder, G.J.; Siest, G.
Selective and potent inhibition of different hepatic UDP-glucuronosyltransferase activities by omega,omega,omega-triphenylalcohols and UDP derivatives (1992), Biochem. Biophys. Res. Commun., 187, 140-145.

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Inhibitors

Inhibitors	Comment	Organism	Structure
7,7,7-triphenylheptyl-UDP	-	Rattus norvegicus
omega,omega,omega-triphenylalkyl-UDP derivatives	e.g. 7,7,7-triphenylheptyl-UDP	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Wistar strain	-
Rattus norvegicus Wistar	-	Wistar strain	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-naphthol + UDP-glucuronate	-	Rattus norvegicus	naphth-1-yl-beta-D-glucuronide + UDP	-	?
1-naphthol + UDP-glucuronate	-	Rattus norvegicus Wistar	naphth-1-yl-beta-D-glucuronide + UDP	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.03	-	7,7,7-triphenylheptyl-UDP	apparent Ki for the inhibition of 1-naphthol glucuronidation	Rattus norvegicus

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Release 2023.1 (January 2023)