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Literature summary for 2.4.1.16 extracted from

  • Gyore, J.; Parameswar, A.R.; Hebbard, C.F.; Oh, Y.; Bi, E.; Demchenko, A.V.; Price, N.P.; Orlean, P.
    2-Acylamido analogues of N-acetylglucosamine prime formation of chitin oligosaccharides by yeast chitin synthase 2 (2014), J. Biol. Chem., 289, 12835-12841.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.16

Activating Compound

Activating Compound Comment Organism Structure
N-acetyl-D-glucosamine GlcNAc and 2-acylamido analogues of GlcNAc stimulate formation of chitin oligosaccharides by yeast chitin synthase, and GlcNAc is transferred to the 2-acylamido analogues. Synthesis of chitin oligosaccharides is strongly dependent on inclusion of GlcNAc in chitin synthase incubations. Formation of both chitin oligosaccharides and insoluble chitin is also stimulated by GlcNAc2 Saccharomyces cerevisiae
N-butanoyl-D-glucosamine stimulates formation of both chitin oligosaccharides and insoluble chitin from the 2-acylamido analogues of UDP-N-acetyl-alpha-D-glucosamine Saccharomyces cerevisiae
N-Glycolyl-D-glucosamine stimulates formation of both chitin oligosaccharides and insoluble chitin from the 2-acylamido analogues of UDP-N-acetyl-alpha-D-glucosamine Saccharomyces cerevisiae
N-propanoyl-D-glucosamine stimulates formation of both chitin oligosaccharides and insoluble chitin from the 2-acylamido analogues of UDP-N-acetyl-alpha-D-glucosamine Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Saccharomyces cerevisiae 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n Saccharomyces cerevisiae
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 UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P14180 several strains, gene chs2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information formation of chitin oligosaccharides and insoluble chitin, and by replacing GlcNAc with 2-acylamido analogues of GlcNAc. Synthesis of chitin oligosaccharides is strongly dependent on inclusion of GlcNAc in chitin synthase incubations, and N,N'-diacetylchitobiose is the major reaction product. Formation of both chitin oligosaccharides and insoluble chitin is also stimulated by GlcNAc2 and by N-propanoyl-, N-butanoyl-, and N-glycolylglucosamine Saccharomyces cerevisiae ?
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Saccharomyces cerevisiae UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

Synonyms

Synonyms Comment Organism
chitin synthase 2
-
 Saccharomyces cerevisiae
Chs2
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function chitin synthases transfer GlcNAc from UDP-GlcNAc to preexisting chitin chains in reactions that are typically stimulated by free GlcNAc. The enzyme is involved in biosynthesis of chitin, a homopolymer of beta-1,4-linked GlcNAc residues and a key component of fungal cell walls and the arthropod exoskeleton Saccharomyces cerevisiae