Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-acetyl-D-glucosamine | GlcNAc and 2-acylamido analogues of GlcNAc stimulate formation of chitin oligosaccharides by yeast chitin synthase, and GlcNAc is transferred to the 2-acylamido analogues. Synthesis of chitin oligosaccharides is strongly dependent on inclusion of GlcNAc in chitin synthase incubations. Formation of both chitin oligosaccharides and insoluble chitin is also stimulated by GlcNAc2 | Saccharomyces cerevisiae | |
N-butanoyl-D-glucosamine | stimulates formation of both chitin oligosaccharides and insoluble chitin from the 2-acylamido analogues of UDP-N-acetyl-alpha-D-glucosamine | Saccharomyces cerevisiae | |
N-Glycolyl-D-glucosamine | stimulates formation of both chitin oligosaccharides and insoluble chitin from the 2-acylamido analogues of UDP-N-acetyl-alpha-D-glucosamine | Saccharomyces cerevisiae | |
N-propanoyl-D-glucosamine | stimulates formation of both chitin oligosaccharides and insoluble chitin from the 2-acylamido analogues of UDP-N-acetyl-alpha-D-glucosamine | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Saccharomyces cerevisiae | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | Saccharomyces cerevisiae | - |
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P14180 | several strains, gene chs2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | formation of chitin oligosaccharides and insoluble chitin, and by replacing GlcNAc with 2-acylamido analogues of GlcNAc. Synthesis of chitin oligosaccharides is strongly dependent on inclusion of GlcNAc in chitin synthase incubations, and N,N'-diacetylchitobiose is the major reaction product. Formation of both chitin oligosaccharides and insoluble chitin is also stimulated by GlcNAc2 and by N-propanoyl-, N-butanoyl-, and N-glycolylglucosamine | Saccharomyces cerevisiae | ? | - |
? | |
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Saccharomyces cerevisiae | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
chitin synthase 2 | - |
Saccharomyces cerevisiae |
Chs2 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | chitin synthases transfer GlcNAc from UDP-GlcNAc to preexisting chitin chains in reactions that are typically stimulated by free GlcNAc. The enzyme is involved in biosynthesis of chitin, a homopolymer of beta-1,4-linked GlcNAc residues and a key component of fungal cell walls and the arthropod exoskeleton | Saccharomyces cerevisiae |