Literature summary for 2.4.1.16 extracted from

Tatsuno, K.; Yamada-Okabe, H.; Takagi, M.; Arisawa, M.; Sudoh, M.
Properties of yeast expressed Aspergillus nidulans chitin synthase B which is essential for hyphal growth (1997), FEMS Microbiol. Lett., 149, 279-284.

Search for more literature for 2.4.1.16

Activating Compound

Activating Compound	Comment	Organism	Structure
GlcNAc	-	Aspergillus nidulans

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae using the GAL1 promoter in a multicopy plasmid	Aspergillus nidulans

Inhibitors

Inhibitors	Comment	Organism	Structure
Cu2+	-	Aspergillus nidulans
EDTA	-	Aspergillus nidulans
Polyoxin D	-	Aspergillus nidulans
Zn2+	-	Aspergillus nidulans

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.6	-	UDP-GlcNAc	-	Aspergillus nidulans

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required for maximal activity	Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n	Aspergillus nidulans	chitin synthase B is essential for hyphal growth	UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Aspergillus nidulans	-	chitin synthase B	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	activated by trypsin	Aspergillus nidulans

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n	-	Aspergillus nidulans	UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1	-	?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n	chitin synthase B is essential for hyphal growth	Aspergillus nidulans	UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	activation by Mg2+	Aspergillus nidulans

pH Range

pH Minimum	pH Maximum	Comment	Organism
6.5	8.5	pH 6.5: about 85% of maximal activity, pH 8.5: about 70% of maximal activity	Aspergillus nidulans

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.01	-	Polyoxin D	-	Aspergillus nidulans

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Release 2023.1 (January 2023)