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Literature summary for 2.4.1.16 extracted from

  • Cabib, E.
    Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins (1991), Antimicrob. Agents Chemother., 35, 170-173.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Nikkomycin competitive; competitive inhibitor of chitin synthetase 2; nikkomycin X and nikkomycin Z; nikkomycin Z is more inhibitory to chitin synthetase 1 than for chitin synthetase 2 Saccharomyces cerevisiae
nikkomycin X
-
Saccharomyces cerevisiae
nikkomycin Z
-
Saccharomyces cerevisiae
Polyoxin D competitive inhibitor of chitin synthetase 2; more inhibitory to chitin synthetase 1 than for chitin synthetase 2 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n Saccharomyces cerevisiae chitin synthetase 2 is essential for primary septum formation, chitin synthetase 1 is a repair enzyme UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
chitin synthetase 1 and 2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
Saccharomyces cerevisiae UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n chitin synthetase 2 is essential for primary septum formation, chitin synthetase 1 is a repair enzyme Saccharomyces cerevisiae UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00014
-
nikkomycin X chitin synthetase 1 Saccharomyces cerevisiae
0.00025
-
nikkomycin Z chitin synthetase 1 Saccharomyces cerevisiae
0.0009
-
5-((2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl)amino)-1-(5-carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,5-dideoxy-beta-D-allofuranuronic acid chitin synthetase 1 Saccharomyces cerevisiae