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Literature summary for 2.4.1.152 extracted from

  • Jezequel-Cuer, M.; N'Guyen-Cong, H.; Biou, D.; Durand, G.
    Oligosaccharide specificity of normal human hepatocyte alpha1-3 fucosyltransferase (1993), Biochim. Biophys. Acta, 1157, 252-258.
    View publication on PubMed
Search for more literature for 2.4.1.152

Inhibitors

Inhibitors Comment Organism Structure
GDP-choline 0.5 mM, 90% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0065
-
 GDP-fucose pH 7.2, 37°C Homo sapiens
0.38
-
 alpha(2,3) bisialylated biantennary glycan pH 7.2, 37°C Homo sapiens
0.65
-
 3'-sialyl N-acetyl lactosamine pH 7.2, 37°C Homo sapiens
0.74
-
 unsialylated biantennary glycan pH 7.2, 37°C Homo sapiens
2.6
-
 N-acetyl lactosamine pH 7.2, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi vesicle
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the hepatocellular enzyme is involved in the synthesis of sialosyl LeX determinants on cirrhotic alpha1AGP ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000002
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-beta-L-fucose + alpha(2,3) bisialylated biantennary glycan
-
 Homo sapiens ?
-
 ?
GDP-beta-L-fucose + unsialylated biantennary glycan
-
 Homo sapiens ?
-
 ?
GDP-L-fucose + 3'-sialyl N-acetyl lactosamine
-
 Homo sapiens GDP + ?
-
 ?
GDP-L-fucose + asialotransferrin
-
 Homo sapiens GDP + ?
-
 ?
GDP-L-fucose + Fucalpha(1,2)Galbeta(1,4)Glc
-
 Homo sapiens GDP + Fucalpha(1,2)Galbeta(1,4)(Fucalpha(1,3))Glc
-
 ?
GDP-L-fucose + Galbeta(1,4)GlcNAc i.e. N-acetyllactosamine Homo sapiens GDP + Galbeta(1,4)(Fucalpha(1,3))GlcNAc
-
 ?
GDP-L-fucose + lactose weak activity Homo sapiens GDP + ?
-
 ?
additional information the hepatocellular enzyme is involved in the synthesis of sialosyl LeX determinants on cirrhotic alpha1AGP Homo sapiens ?
-
 ?