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Literature summary for 2.4.1.152 extracted from

  • Kannagi, R.
    alpha3-Fucosyltransferase-VI (FUT6) (2002), Handbook of Glycosyltransferases and Related Genes; (Taniguchi, N. ; Honk, K. ; Fukuda, M. , eds. ), , 237-245.
No PubMed abstract available
Search for more literature for 2.4.1.152

Inhibitors

Inhibitors Comment Organism Structure
diethyldicarbonate
-
 Homo sapiens
NEM
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi trans-face
-
 Homo sapiens
-
-
secretory granule granules of endothelial cells (Weibel-Parade bodies) Homo sapiens 30141
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ 20 mM Mn2+ are required for full activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder transcript of FUT6 mRNA detected Homo sapiens
-
blood plasma in individuals with plasma fucosyltransferase deficiency from Indonesia, either a missense mutation, G739A, in the catalytic domain, or a nonsense mutation, C945A, truncating the COOH terminus of the enzyme, leads to the total loss of the enzymatic activity of FUT6. 9% of individuals on the island of Java lack the plasma type enzyme. Activity is elevated in patients with a variety of malignant disorders, including liver cancer, elevated in heavy alcohol drinkers. Reduction of enzyme level in patients with schizophrenia Homo sapiens
-
colon transcript of FUT6 mRNA detected Homo sapiens
-
endothelial cell
-
 Homo sapiens
-
kidney transcript of FUT6 mRNA detected Homo sapiens
-
liver transcript of FUT6 mRNA detected Homo sapiens
-
milk
-
 Homo sapiens
-
saliva
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
uterus transcript of FUT6 mRNA detected Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Bos taurus ?
-
 ?
additional information enzyme utilizes only type-2 chain polylactosamines as substrates, sialylated and nonsialylated oligosaccharides are good substrates, the enzyme produces sialyl Lewis X and Lewis X determinants Homo sapiens ?
-
 ?
additional information the enzyme is active on the polylactosamine substrate having 6-sulfate modification at the GlcNAc moiety and gives rise to sialyl and nonsialyl 6-sulfo Lewis X. The enzyme is also active on alpha(1,2) fucosylated type 2 chain substrates Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 8
-
 Homo sapiens