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Literature summary for 2.4.1.15 extracted from
- The sugar sensor, trehalose-6-phosphate synthase (tps1), regulates primary and secondary metabolism during infection by the rice blast fungus: will magnaporthe oryzaes sweet tooth become its achilles heel? (2011), Mycology, 2, 46-53.
No PubMed abstract available
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-glucose + D-glucose 6-phosphate | Pyricularia oryzae | - |
UDP + alpha,alpha-trehalose 6-phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pyricularia oryzae | - |
gene tps1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| conidium | - |
Pyricularia oryzae | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-glucose + D-glucose 6-phosphate | - |
Pyricularia oryzae | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TPS1 | - |
Pyricularia oryzae |
| trehalose-6-phosphate synthase | - |
Pyricularia oryzae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | DELTAtps1 strains have reduced NADPH levels during growth on nitrate-containing media due to decreased G6PDH activity | Pyricularia oryzae |
| metabolism | the first step in trehalose biosynthesis involves trehalose 6-phosphate synthase, Tps1 | Pyricularia oryzae |
| physiological function | the non-reducing disaccharide, trehalose, is present in conidia of the fungus and is mobilized during appressorium formation. Trehalose 6-phosphate synthase protein ia a regulator during infection by the rice blast fungus Magnaporthe oryzae. Tps1 functions as a sugar sensor to integrate carbon and nitrogen metabolism and regulate a subset of primary and secondary metabolic pathways, such as the oxidative pentose phosphate pathway and pigment formation, respectively, during plant colonization, allowing the fungus to adapt to the nutritional and redox conditions encountered in the plant cell and establish disease. Tps1 regulates gene expression via the modulation of NADPH. Tps1 also regulates Nmr activity, involved in nitrogen metabolism, mechanism, overview | Pyricularia oryzae |
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