Literature summary for 2.4.1.15 extracted from

Chen, X.M.; Jiang, Y.; Li, Y.T.; Zhang, H.H.; Li, J.; Chen, X.; Zhao, Q.; Zhao, J.; Si, J.; Lin, Z.W.; Zhang, H.; Dyson, P.; An, L.Z.
Regulation of expression of trehalose-6-phosphate synthase during cold shock in Arthrobacter strain A3 (2011), Extremophiles, 15, 499-508.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	increase of trehalose in the first 2-3 h of cold shock	Arthrobacter sp.

Cloned(Commentary)

Cloned (Comment)	Organism
gene otsA, DNA amnd amino acid sequence determination and analysis	Arthrobacter sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-alpha-D-glucose + D-glucose 6-phosphate	Arthrobacter sp.	-	UDP + alpha,alpha-trehalose 6-phosphate	-	?
UDP-alpha-D-glucose + D-glucose 6-phosphate	Arthrobacter sp. A3	-	UDP + alpha,alpha-trehalose 6-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Arthrobacter sp.	C7EZF1	isolated from the alpine permafrost, CGMCC 1.8987, gene otsA	-
Arthrobacter sp. A3	C7EZF1	isolated from the alpine permafrost, CGMCC 1.8987, gene otsA	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-alpha-D-glucose + D-glucose 6-phosphate	-	Arthrobacter sp.	UDP + alpha,alpha-trehalose 6-phosphate	-	?
UDP-alpha-D-glucose + D-glucose 6-phosphate	-	Arthrobacter sp. A3	UDP + alpha,alpha-trehalose 6-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
OtsA	-	Arthrobacter sp.

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
4	-	-	Arthrobacter sp.

Temperature Range [°C]

Temperature Minimum [°C]	Temperature Maximum [°C]	Comment	Organism
4	20	catalytic activity of OtsA at 4°C is 1.2fold greater than that at 20°C	Arthrobacter sp.

Expression

Organism	Comment	Expression
Arthrobacter sp.	both low temperature and accumulation of trehalose can inhibit OtsA expression, increase of trehalose in the first 2.3 h of cold shock	down

General Information

General Information	Comment	Organism
evolution	Arthrobacter strain A3 has only two trehalose synthesis pathways (OtsA/B and TreS), while other Arthrobacter spp. have three	Arthrobacter sp.
physiological function	regulation of OtsA expression during cold shock, both low temperature and accumulation of trehalose can inhibit OtsA expression, overview	Arthrobacter sp.

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Release 2023.1 (January 2023)