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Literature summary for 2.4.1.147 extracted from

  • Vavasseur, F.; Yang, J.M.; Dole, K.; Paulsen, H.; Brockhausen, I.
    Synthesis of O-glycan core 3: characterization of UDP-GlcNAc:GalNAc-R beta3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines (1995), Glycobiology, 5, 351-357.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NP 40 activation Rattus norvegicus
Triton X-100 stimulation, 0.1% v/v, inhibits at concentrations above 0.5% v/v Rattus norvegicus

General Stability

General Stability Organism
enzyme is extremly unstable in solubilized form Homo sapiens
enzyme is extremly unstable in solubilized form Rattus norvegicus
repeated freezing and thawing results in total loss of activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
deoxycholate total inactivation Rattus norvegicus
N-iodoacetamido-galactosamine-alpha-benzyl colon homogenates, 50% inhibition at 2 mM Homo sapiens
NaCl slight inhibition at 0.1 M Rattus norvegicus
PMSF slight inhibition at 1 mM Rattus norvegicus
Triton X-100 0.5% reduces activity by 60% Rattus norvegicus
Triton X-114 slight stimulation Rattus norvegicus
UDP 60% reduced activity at 10 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-
membrane
-
Rattus norvegicus 16020
-
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Homo sapiens
-
colon
-
Rattus norvegicus
-
additional information no activity in diverse cancer cell lines Homo sapiens
-
additional information tissue-specific expression Homo sapiens
-
additional information tissue-specific expression Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 2-azido-2-deoxy-alpha-D-galactosyl-benzyl
-
Homo sapiens UDP + 3-O-(N-acetyl-beta-D-glucosaminyl)-2-azido-2-deoxy-alpha-D-galactosyl-benzyl
-
?
UDP-N-acetyl-D-glucosamine + 4-nitrophenyl N-acetyl-alpha-D-galactosaminide
-
Homo sapiens UDP + 4-nitrophenyl N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminide
-
?
UDP-N-acetyl-D-glucosamine + alpha-D-galactosaminyl-4-nitrophenyl
-
Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-alpha-D-galactosaminyl-4-nitrophenyl
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-alpha-D-galactosaminyl-(CH2)2NHCO(CH2)3CO2CH3
-
Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-(CH2)2NHCO(CH2)3CO2CH3
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-alpha-D-galactosaminyl-benzyl
-
Rattus norvegicus UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-alpha-D-galactosaminyl-benzyl best substrate Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-R substrate specificity is significantly influenced by the structure of the aglycon group Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R
-
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-R substrate specificity is significantly influenced by the structure of the aglycon group Rattus norvegicus UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R
-
?
UDP-N-acetyl-D-glucosamine + ovine submaxillary gland mucin acceptor substrate is desialylated, degalactosylated, defucosylated Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,3-mucin of ovine submaxillary gland
-
?
UDP-N-acetyl-D-glucosamine + ovine submaxillary gland mucin acceptor substrate is desialylated, degalactosylated, defucosylated Rattus norvegicus UDP + N-acetyl-beta-D-glucosaminyl-1,3-mucin of ovine submaxillary gland
-
?

Synonyms

Synonyms Comment Organism
core 3 beta3-GlcNAc-T
-
Homo sapiens
core 3 beta3-GlcNAc-T
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7 assay at Homo sapiens
6.5 7 assay at Rattus norvegicus