Cloned (Comment) | Organism |
---|---|
enzyme overexpression in HeLa-S3, CHO-K1, Pro-5, and MDA-MB-231 cells using vector CSIV-TRE-RfA-CMV-KT, cloning in HEK-293T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of GnT-III significantly inhibits alpha2,3-sialylation but not alpha2,6-sialylation. The migratory ability of cells, HeLa-S3, CHO-K1 and Pro-5, without or with a low level of alpha2,6-sialylation is consistently suppressed after overexpression of GnT-III, while in alpha2,6-hypersialylated MDA-MB-231 and MKN-45 cells little effects are observed. Phenotypes, detailed overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q09327 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | - |
Homo sapiens | - |
HEK-293T cell | - |
Homo sapiens | - |
HeLa-S3 cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
ovarian cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GnT-III | - |
Homo sapiens |
N-acetylglucosaminyltransferase III | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | interplay between GnT-III and sialyltransferases in the expression of their enzymatic products and also their functions in tumor metastasis. Interplay between GnT-III and ST6GAL1 in regulating cell migration | Homo sapiens |
physiological function | N-acetylglucosaminyltransferase III catalyzes the addition of the bisecting GlcNAc branch on N-glycans, and is a metastasis suppressor with an important role of GnT-III in N-glycan biosynthesis and tumor cell behaviours. Increased expression of GnT-III in human hepatomas, glioma, and ovarian cancers. Overexpression of GnT-III significantly inhibits alpha2,3-sialylation but not alpha2,6-sialylation via post-transcriptional mechanisms. GnT-III plays an anti-migratory role in tumor cells without or with a low level of alpha2,6-linked sialic acids but not in those alpha2,6-hypersialylated | Homo sapiens |