Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
x * 52000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE | Mus musculus |
52000 | - |
x * 52000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE | Homo sapiens |
62000 | - |
x * 62000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE | Mus musculus |
62000 | - |
x * 62000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GE-11 cell | - |
Mus musculus | - |
MCF-10A cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manbeta(1->3)Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-NH(CH2)4NH(2-pyridyl) | - |
Mus musculus | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manbeta(1->3)Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-NH(CH2)4NH(2-pyridyl) | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 52000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE | Mus musculus |
? | x * 52000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE | Homo sapiens |
? | x * 62000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE | Mus musculus |
? | x * 62000, two major bands migrate at 62000 and 52000 Da, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
GnT-III | - |
Mus musculus |
GnT-III | - |
Homo sapiens |
N-acetylglucosaminyltransferase III | - |
Mus musculus |
N-acetylglucosaminyltransferase III | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the expression levels of GnT-III are suppressed about 25fold in transforming growth factor-beta-treated cells (5 ng/ml) | down |
Homo sapiens | the expression levels of GnT-III are suppressed about 25fold in transforming growth factor-beta-treated cells (5 ng/ml) | down |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays an important role in the suppression of cancer metastasis. The enzyme influences epithelial-to-mesenchymal transition-like changes through not only prolongation of E-cadherin turnover but also suppression of beta-catenin-p-Smad complex formation. The enzyme plays important roles in transforming growth factor-beta-induced epithelial-to-mesenchymal transition-like changes. The enzyme does not significantly affect the expression of E-cadherin mRNA | Mus musculus |
physiological function | the enzyme plays an important role in the suppression of cancer metastasis. The enzyme influences epithelial-to-mesenchymal transition-like changes through not only prolongation of E-cadherin turnover but also suppression of beta-catenin-p-Smad complex formation. The enzyme plays important roles in transforming growth factor-beta-induced epithelial-to-mesenchymal transition-like changes. The enzyme does not significantly affect the expression of E-cadherin mRNA | Homo sapiens |