Literature summary for 2.4.1.144 extracted from

Gu, J.; Zhao, Y.; Isaji, T.; Shibukawa, Y.; Ihara, H.; Takahashi, M.; Ikeda, Y.; Miyoshi, E.; Honke, K.; Taniguchi, N.
beta1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells (2004), Glycobiology, 14, 177-186.

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Application

Application	Comment	Organism
synthesis	RC12 cells, apheochromocytoma cell line, transfected with enzyme gene, result in suppression of neurite outgrowth induced by costimulation of epidermal growth factor and integrins. Epidermal growth factor receptor-mediated ERK-activation is blocked in transfectants. Epidermal growth factor receptor of transfectants is modified by bisecting GlcNAc in its N-glycan structures	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	enzyme transfected to RC12 cells, a pheochromocytoma cell line	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)