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Literature summary for 2.4.1.144 extracted from

  • Taniguchi, N.; Yoshimura, M.; Miyoshi, E.; Ihara, Y.; Nishikawa, A.; Kang, R.; Ikeda, Y.
    Gene expression and regulation of N-acetylglucosaminyltransferases III and V in cancer tissues (1998), Adv. Enzyme Regul., 38, 223-232.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in murine lung melanoma cell line B16-hm, leading to suppression of the formation of beta-1,6-tri- and tetraantennary N-linked oligosaccharides by inhibiting the responsible enzymes, e.g. N-acetylglucosamine transferase V, EC 2.4.1.155, decrease of the metastatic potential of B16-hm melanoma in vivo, changed phenotype Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Homo sapiens
additional information transgenic expression of the enzyme in hepatitis B virus infected cells suppress the virus expression, cell line HB611 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
no activity in Mus musculus
-
lung melanoma cell line B16-hm
-

Source Tissue

Source Tissue Comment Organism Textmining
HB611 cell hepatoblastoma cell line, derived from Huh6 by transfection of 3 copies of hepatitis B virus genome, decreased transcription level Homo sapiens
-
HuH-6 cell hepatoblastoma cell line Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000001
-
HB611 cells Homo sapiens
0.0000023
-
Huh6 cells Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R incorporates a N-acetylglucosamine residue in beta-1,4-linkage to beta-linked mannosyl, i.e. bisecting N-acetylglucosamine ?

Synonyms

Synonyms Comment Organism
GnT-III
-
Homo sapiens