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Literature summary for 2.4.1.143 extracted from

  • Mucha, J.; Svoboda, B.; Kappel, S.; Strasser, R.; Bencur, P.; Froehwein, U.; Schachter, H.; Mach, L.; Gloessl, J.
    Two closely related forms of UDP-GlcNAc:alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II occur in the clawed frog Xenopus laevis (2003), Glycoconj. J., 19, 187-195.
    View publication on PubMed
Search for more literature for 2.4.1.143

Cloned(Commentary)

Cloned (Comment) Organism
heterologous expression in insect cells Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane enzyme exhibits a type II transmembrane protein topology with a putative N-terminal cytoplasmic tail of 9 amino acids followed by transmembrane domain of 18 residues, and a C-terminal luminal domain of 405 residues Xenopus laevis 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R Xenopus laevis the enzyme catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides UDP + N-acetyl-beta-D-glucosaminyl 1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R
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 ?

Organism

Organism UniProt Comment Textmining
Xenopus laevis Q7ZZX7 Gnt II-A
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Xenopus laevis Q7ZZX7 Gnt II-B
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Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-linked oligosaccharides Xenopus laevis

Purification (Commentary)

Purification (Comment) Organism
-
 Xenopus laevis

Source Tissue

Source Tissue Comment Organism Textmining
heart
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 Xenopus laevis
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kidney
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 Xenopus laevis
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liver
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 Xenopus laevis
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lung
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 Xenopus laevis
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muscle
-
 Xenopus laevis
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ovary
-
 Xenopus laevis
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skin
-
 Xenopus laevis
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spleen
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 Xenopus laevis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R the enzyme catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides Xenopus laevis UDP + N-acetyl-beta-D-glucosaminyl 1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R
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 ?
UDP-N-acetyl-D-glucosamine + Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
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 Xenopus laevis UDP + GlcNAcbeta(1-2)Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
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 ?

Synonyms

Synonyms Comment Organism
Gnt II-A
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 Xenopus laevis
Gnt II-B
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 Xenopus laevis
UDP-GlcNAc:alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II
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 Xenopus laevis