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Literature summary for 2.4.1.135 extracted from

  • Hiyama, A.; Gogate, S.S.; Gajghate, S.; Mochida, J.; Shapiro, I.M.; Risbud, M.V.
    BMP-2 and TGFbeta stimulate expression of beta1,3 glucuronosyl transferase-I (GlcAT-I) in nucleus pulposus cells through AP1, TonEBP and Sp1: Role of Map kinases (2010), J. Bone Miner. Res., 25, 1179-1190.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser Rattus norvegicus
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 UDP + GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
nucleus pulposus
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 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
-
 Rattus norvegicus UDP + GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
-
 ?

Synonyms

Synonyms Comment Organism
galactose beta1,3 glucuronosyl transferase-I
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 Rattus norvegicus
GlcAT-I
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 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus treatment with both BMP-2 (200 ng/ml) and TGFbeta (10 ng/ml) for 24 h results in increased GlcAT-I mRNA levels in nucleus pulposus cells, however, simultaneous treatment of nucleus pulposus cells with TGFbeta and BMP-2 does not synergize GlcAT-I mRNA expression. GlcAT-I regulation is mediated through transcription factors AP1, Sp1, and TonEBP (NFAT5). Treatment with MAPK inhibitors blocks BMP-2 and TGFbeta induced GlcAT-I expression. p38delta is important in GlcAT-I activation up