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Literature summary for 2.4.1.135 extracted from

  • Hiyama, A.; Gajghate, S.; Sakai, D.; Mochida, J.; Shapiro, I.M.; Risbud, M.V.
    Activation of TonEBP by calcium controls beta1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc (2009), J. Biol. Chem., 284, 9824-9834.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser Rattus norvegicus
-
 UDP + GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
nucleus pulposus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
-
 Rattus norvegicus UDP + GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
-
 ?

Synonyms

Synonyms Comment Organism
beta1,3-glucuronosyltransferase-I
-
 Rattus norvegicus
galactose beta1,3-glucuronosyltransferase-I
-
 Rattus norvegicus
GlcAT-I
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus GlcAT-I promoter activity is suppressed by co-expression of calcineurin and nuclear factors of activated T cells 2, 3, and 4, treatment with WP631 at 50-100 nM completely abolishes ionomycin-mediated induction in GlcAT-I-D reporter activity as well as suppressing basal promoter activity down
Rattus norvegicus treatment with 0.001 mM ionomycin for 24 h results in increased GlcAT-I expression, ionomycin mediated induction of GlcAT-I promoter activity requires TonEBP binding to TonE, calcium regulates GlcAT-I expression in cells of the nucleus pulposus up