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Literature summary for 2.4.1.133 extracted from

  • Yang, H.; Hu, L.; Chen, J.; Zhu, J.; Tao, T.; Zhang, F.; Li, X.; He, X.; Shen, A.; Cheng, C.
    Lipopolysaccharide induced upregulation of beta-1,4-galactosyltransferase-I in Schwann cell (2009), Inflammation, 32, 279-286.
    View publication on PubMed
Search for more literature for 2.4.1.133

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Rattus norvegicus 5794
-
membrane of Schwann cells Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme transfers galactose to the terminal N-acetylglucosamine of N- and O-linked glycans in a beta-1,4-linkage ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Schwann cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme transfers galactose to the terminal N-acetylglucosamine of N- and O-linked glycans in a beta-1,4-linkage Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase-I
-
 Rattus norvegicus
beta-1,4-GalT-I
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus beta-1,4-GalT-I mRNA is significant increased as early as 2 h after lipopolysaccharide stimulation (1 microM/ml), upregulation in a time- and concentration-dependent manner up

General Information

General Information Comment Organism
physiological function beta-1,4-GalT-I may play an important role in adhesion and migration of Schwann cells during inflammation, enzyme is a key inflammatory mediator that participates in the initiation and maintenance of inflammatory reaction in diseases, the long beta-1,4-GalT-I isoform, due to the extra 13 amino acids at the amino-termini, is implicated in targeting the protein to cell surface, and acts as a recognition molecule associated with a variety of biological functions, including sperm-egg interactions, morula compaction, embryonic maturation, embryonal carcinoma cell spreading, neurite extension, and mesenchymal cell migration Rattus norvegicus