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Literature summary for 2.4.1.133 extracted from

  • Yan, M.; Xia, C.; Niu, S.; Cheng, C.; Shao, X.; Shen, A.
    The role of TNF-alpha and its receptors in the production of beta-1,4-galactosyltransferase I mRNA by rat primary type-2 astrocytes (2008), Cell. Mol. Neurobiol., 28, 223-236.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P80225
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary type 2 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase I
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Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus both anti-TNFR1 and anti-TNFR2 antibodies suppressed beta-1,4-GalT I mRNA expression induced by tumor necrosis factor-alpha or lipopolysaccharide down
Rattus norvegicus the expression level of beta-1,4-GalT I mRNA in cultured type-2 astrocytes is dose-dependent compared with the control group, it decreases at 0.1 ng/ml tumor necrosis factor-alpha, reaches at a peak at 1 ng/ml and then restores to normal level at 5 ng/ml. The expression in cultured type-2 astrocytes is time-dependent, it increases from 0.5 h, peaks at 4 h, then it decreases gradually to normal level after exposure to 1 ng/ml tumor necrosis factor-alpha. Lipopolysaccharide induces beta-1,4-GalT I mRNA expression in type-2 astrocytes in a time- and dose-dependent manner up

General Information

General Information Comment Organism
physiological function enzyme plays in important role in the synthesis of the backbone structure of adhesion molecules involved in leukocyte-endothelial cell interaction Rattus norvegicus