Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P80225 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | primary type 2 | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
beta-1,4-galactosyltransferase I | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | both anti-TNFR1 and anti-TNFR2 antibodies suppressed beta-1,4-GalT I mRNA expression induced by tumor necrosis factor-alpha or lipopolysaccharide | down |
Rattus norvegicus | the expression level of beta-1,4-GalT I mRNA in cultured type-2 astrocytes is dose-dependent compared with the control group, it decreases at 0.1 ng/ml tumor necrosis factor-alpha, reaches at a peak at 1 ng/ml and then restores to normal level at 5 ng/ml. The expression in cultured type-2 astrocytes is time-dependent, it increases from 0.5 h, peaks at 4 h, then it decreases gradually to normal level after exposure to 1 ng/ml tumor necrosis factor-alpha. Lipopolysaccharide induces beta-1,4-GalT I mRNA expression in type-2 astrocytes in a time- and dose-dependent manner | up |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme plays in important role in the synthesis of the backbone structure of adhesion molecules involved in leukocyte-endothelial cell interaction | Rattus norvegicus |