BRENDA - Enzyme Database
show all sequences of 2.4.1.132

Activation of mannosyltransferase II by nonbilayer phospholipids

Jensen, J.W.; Schutzbach, J.S.; Biochemistry 23, 1115-1119 (1984)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
phosphatidylethanolamine
activation
Oryctolagus cuniculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Phospholipids
stable bilayer forming, e.g. phosphatidylcholine, restorable by addition of cholesterol, dolichol and dolichol-derivatives
Oryctolagus cuniculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Oryctolagus cuniculus
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
GDPmannose + tetrasaccharide-diphosphoryl-lipid
Oryctolagus cuniculus
involved in the biosynthesis of asparagine-linked saccharide chains of mammalian glycoproteins
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
-
-
GDPmannose + tetrasaccharide-diphosphoryl-lipid
Oryctolagus cuniculus
the 1,3-linked mannosyl residue in mammalian lipid-linked oligosaccharide of the structure Glc3Man9GlcNAc2 is produced by this enzyme
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oryctolagus cuniculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Storage Stability
Storage Stability
Organism
glycerol, 10% v/v, stabilizes during storage
Oryctolagus cuniculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
GDPmannose + tetrasaccharide-diphosphoryl-lipid
-
636753
Oryctolagus cuniculus
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
636753
Oryctolagus cuniculus
?
GDPmannose + tetrasaccharide-diphosphoryl-lipid
involved in the biosynthesis of asparagine-linked saccharide chains of mammalian glycoproteins
636753
Oryctolagus cuniculus
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
-
-
-
GDPmannose + tetrasaccharide-diphosphoryl-lipid
the 1,3-linked mannosyl residue in mammalian lipid-linked oligosaccharide of the structure Glc3Man9GlcNAc2 is produced by this enzyme
636753
Oryctolagus cuniculus
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Oryctolagus cuniculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
phosphatidylethanolamine
activation
Oryctolagus cuniculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Phospholipids
stable bilayer forming, e.g. phosphatidylcholine, restorable by addition of cholesterol, dolichol and dolichol-derivatives
Oryctolagus cuniculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Oryctolagus cuniculus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
GDPmannose + tetrasaccharide-diphosphoryl-lipid
Oryctolagus cuniculus
involved in the biosynthesis of asparagine-linked saccharide chains of mammalian glycoproteins
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
-
-
GDPmannose + tetrasaccharide-diphosphoryl-lipid
Oryctolagus cuniculus
the 1,3-linked mannosyl residue in mammalian lipid-linked oligosaccharide of the structure Glc3Man9GlcNAc2 is produced by this enzyme
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Storage Stability (protein specific)
Storage Stability
Organism
glycerol, 10% v/v, stabilizes during storage
Oryctolagus cuniculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
GDPmannose + tetrasaccharide-diphosphoryl-lipid
-
636753
Oryctolagus cuniculus
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
636753
Oryctolagus cuniculus
?
GDPmannose + tetrasaccharide-diphosphoryl-lipid
involved in the biosynthesis of asparagine-linked saccharide chains of mammalian glycoproteins
636753
Oryctolagus cuniculus
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
-
-
-
GDPmannose + tetrasaccharide-diphosphoryl-lipid
the 1,3-linked mannosyl residue in mammalian lipid-linked oligosaccharide of the structure Glc3Man9GlcNAc2 is produced by this enzyme
636753
Oryctolagus cuniculus
GDP + mannosyl-alpha-1,3-tetrasaccharide-diphosphoryl-lipid
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Oryctolagus cuniculus
Other publictions for EC 2.4.1.132
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736467
Imamura
Human immunodeficiency virus t ...
Mus musculus, Mus musculus C57/BL6J
J. Biol. Chem.
289
9865-9879
2014
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1
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1
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1
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7
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1
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1
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7
-
-
-
-
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-
-
-
-
-
-
-
1
3
3
1
-
-
735876
Cossins
Congenital myasthenic syndrome ...
Homo sapiens, Mus musculus
Brain
136
944-956
2013
-
-
2
-
3
-
-
-
2
-
-
-
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4
-
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1
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3
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2
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1
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-
-
-
-
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5
5
-
-
-
709008
Kämpf
Biochemical characterization a ...
Saccharomyces cerevisiae
J. Biol. Chem.
284
11900-11912
2009
-
-
-
-
20
-
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-
1
-
-
1
-
1
-
1
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-
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2
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1
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1
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20
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1
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1
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1
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2
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1
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1
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-
707472
O'Reilly
In vitro evidence for the dual ...
Saccharomyces cerevisiae
Biochemistry
45
9593-9603
2006
-
-
1
-
3
-
-
-
1
-
-
1
-
1
-
-
1
-
-
-
-
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3
-
1
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1
-
-
-
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1
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3
-
-
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1
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1
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-
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1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
658848
Gao
Physical interactions between ...
Saccharomyces cerevisiae
Glycobiology
14
559-570
2004
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
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1
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-
636759
Thiel
A new type of congenital disor ...
Homo sapiens, Saccharomyces cerevisiae, Saccharomyces cerevisiae A
J. Biol. Chem.
278
22498-22505
2003
-
1
2
-
3
-
-
-
-
-
-
3
-
14
-
-
-
-
-
1
-
-
4
-
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1
3
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3
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3
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1
-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
636760
Lellouch
Phytanyl-pyrophosphate-linked ...
Komagataeibacter xylinus
Biochem. Biophys. Res. Commun.
272
290-292
2000
-
-
-
-
-
-
-
-
-
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-
1
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1
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2
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636761
Doering
-
alpha-1,3-Mannosyltransferase ...
Cryptococcus neoformans
PCT Int. Appl.
2000
38pp
2000
-
1
-
-
-
-
1
-
-
-
-
-
-
1
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1
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1
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1
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-
1
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-
-
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-
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-
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-
-
-
-
636757
Romero
Mnt2p and Mnt3p of Saccharomyc ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae A
Glycobiology
9
1045-1051
1999
-
-
1
-
-
-
-
-
1
-
-
2
-
10
-
-
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6
-
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1
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1
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2
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-
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6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636763
Doering
A unique alpha-1,3-mannosyltra ...
Cryptococcus neoformans
J. Bacteriol.
181
5482-5488
1999
-
1
-
-
-
-
3
-
1
-
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1
-
1
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1
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1
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3
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1
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1
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1
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636764
Reynolds
The high osmolarity glycerol r ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae A
J. Cell Biol.
143
935-946
1998
-
-
-
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1
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1
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10
-
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1
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1
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636765
Wiggins
Activity of the yeast MNN1 alp ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae A
Proc. Natl. Acad. Sci. USA
95
7945-7940
1998
-
-
-
-
1
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10
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2
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1
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2
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636766
Shpakov
Yeast dolichol-coupled mannosy ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae A
Zh. Evol. Biokhim. Fiziol.
32
3-18
1996
-
-
1
-
-
-
-
-
-
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10
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2
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1
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2
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636755
Graham
Sorting of yeast alpha 1,3 man ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae A
Mol. Biol. Cell
6
809-824
1995
-
-
1
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1
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1
2
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9
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1
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4
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4
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636756
Graham
Clathrin-dependent localizatio ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae A
J. Cell. Biol.
127
667-678
1994
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1
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9
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636762
Yip
Cloning and analysis of the Sa ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae A
Proc. Natl. Acad. Sci. USA
91
2723-2727
1994
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1
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1
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9
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636753
Jensen
-
Activation of mannosyltransfer ...
Oryctolagus cuniculus
Biochemistry
23
1115-1119
1984
1
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1
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1
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2
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1
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1
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3
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1
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1
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3
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1
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636768
Herscovics
Solubilization of an alpha-(1- ...
Bos taurus
FEBS Lett.
156
298-302
1983
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1
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1
1
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1
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636754
Jensen
The biosynthesis of oligosacch ...
Oryctolagus cuniculus
J. Biol. Chem.
257
9025-9029
1982
3
-
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2
1
1
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3
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1
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1
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1
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1
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636752
Jensen
The biosynthesis of oligosacch ...
Oryctolagus cuniculus
J. Biol. Chem.
256
12899-12904
1981
3
-
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-
1
15
2
1
4
-
2
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3
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1
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1
1
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3
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1
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1
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3
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1
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15
-
2
1
4
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2
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1
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1
1
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3
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1
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1
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