Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.122 extracted from

  • Guzman-Aranguez, A.; Woodward, A.M.; Pintor, J.; Argueeso, P.
    Targeted disruption of core 1 beta1,3-galactosyltransferase (C1galt1) induces apical endocytic trafficking in human corneal keratinocytes (2012), PLoS ONE, 7, e36628.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cornea
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
C1GALT1
-
Homo sapiens
core 1 beta1,3-galactosyltransferase
-
Homo sapiens
T-synthase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction abrogation of the enzyme promotes membrane protein internalization. Disruption of core 1 O-glycosyltransferase activity induces endocytosis and faster accumulation of cell surface proteins in cytoplasmic vesicles and induces clathrin-mediated endocytosis. Enzyme-deficient human corneal keratinocytes display plasma membrane invaginations on the apical surface Homo sapiens
physiological function core 1 O-glycosylation is required to maintain transcellular barrier function. Core 1 O-glycans contribute to maintenance of apical barrier function on exposed mucosal surfaces by preventing clathrin-mediated endocytosis Homo sapiens