Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cornea | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
C1GALT1 | - |
Homo sapiens |
core 1 beta1,3-galactosyltransferase | - |
Homo sapiens |
T-synthase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | abrogation of the enzyme promotes membrane protein internalization. Disruption of core 1 O-glycosyltransferase activity induces endocytosis and faster accumulation of cell surface proteins in cytoplasmic vesicles and induces clathrin-mediated endocytosis. Enzyme-deficient human corneal keratinocytes display plasma membrane invaginations on the apical surface | Homo sapiens |
physiological function | core 1 O-glycosylation is required to maintain transcellular barrier function. Core 1 O-glycans contribute to maintenance of apical barrier function on exposed mucosal surfaces by preventing clathrin-mediated endocytosis | Homo sapiens |