Literature summary for 2.4.1.122 extracted from

Williams, S.A.; Stanley, P.
Mouse fertility is enhanced by oocyte-specific loss of core 1-derived O-glycans (2008), FASEB J., 22, 2273-2284.

Search for more literature for 2.4.1.122

Cloned(Commentary)

Cloned (Comment)	Organism
generation of mutant mice, oocyte-specific deletion of T-synthase	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
core 1 beta1,3-galactosyltransferase	-	Mus musculus
T-synthase	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	oocyte-specific deletion at the primary follicle stage of T-synthase leads to a sustained increase in fertility mutant females ovulated 30-50% more eggs and has a sustained increase in litter size compared to controls, ovarian weights and follicle numbers are greater in mutants, but follicular apoptosis is not decreased, the number of follicles entering the growing pool is unaltered, but 3-week mutants ovulate fewer eggs, suggesting that increased fertility results from prolonged follicle development, T-synthase mutant ovaries also contain numerous multiple-oocyte follicles that appeared to form by adjacent, predominantly preantral, follicles joining	Mus musculus
physiological function	T-synthase generates core 1-derived O-glycans	Mus musculus

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Release 2023.1 (January 2023)