Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.122 extracted from

  • Lin, Y.R.; Reddy, B.V.; Irvine, K.D.
    Requirement for a core 1 galactosyltransferase in the Drosophila nervous system (2008), Dev. Dyn., 237, 3703-3714.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.122

Cloned(Commentary)

Cloned (Comment) Organism
cloning of the C-terminal catalytic domain (amino acids 44-388) of C2GalTA into the vector pMT(1B) and transfected into S2 cells Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q7JRF9 isoform A
-
Drosophila melanogaster Q7K237
-
-
Drosophila melanogaster Q7K509 isoform B
-

Source Tissue

Source Tissue Comment Organism Textmining
amnioserosa in embryo Drosophila melanogaster
-
central nervous system in embryo Drosophila melanogaster
-
embryo
-
 Drosophila melanogaster
-
gut in larvae Drosophila melanogaster
-
imago in larvae Drosophila melanogaster
-
larva
-
 Drosophila melanogaster
-
nervous system in larvae Drosophila melanogaster
-
salivary gland
-
 Drosophila melanogaster
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 C1GalTA exhibits high activity on Tn and glycopeptide substrates, although it also exhibits weaker activity on glycolipids Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage Drosophila melanogaster ?
-
 ?

Synonyms

Synonyms Comment Organism
C1GalTA
-
 Drosophila melanogaster
core 1 galactosyltransferase A
-
 Drosophila melanogaster
core 1 GalT
-
 Drosophila melanogaster
galactosyltransferase
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction C1GalTA null mutant is lethal, mutant animals exhibit a striking morphogenetic defect in which the ventral nerve cord is greatly elongated and the brain hemispheres are misshapen Drosophila melanogaster
physiological function C1GalTA is required for nervous system morphogenesis, C1GalTA is required for laminin O-glycosylation Drosophila melanogaster