Literature summary for 2.4.1.11 extracted from

Montori-Grau, M.; Minor, R.; Lerin, C.; Allard, J.; Garcia-Martinez, C.; de Cabo, R.; Gomez-Foix, A.M.
Effects of aging and calorie restriction on rat skeletal muscle glycogen synthase and glycogen phosphorylase (2009), Exp. Gerontol., 44, 426-433.

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Application

Application	Comment	Organism
medicine	old compared to young rats maintained ad libitum on a standard diet have reduced glycogen synthase activity, lower muscle glycogen synthase protein levels, increased phosphorylation of glycogen synthase at site 3a with less activation in soleus muscle. Age-associated impairments in glycogen synthase protein and activation-phosphorylation are also shown in tibialis anterior muscle. There is an age-associated reduction in glycogen phosphorylase activity level in soleus, while brain/muscle isoforms of glycogen phosphorylase protein levels are higher. Calorie restriciton does not alter glycogen synthase or glycogen phosphatase activity/protein levels in young rats. Calorie restriction hinders age-related decreases in glycogen synthase activity/protein, unrelated to glycogen synthase mRNA levels, and glycogen synthase inactivation-phosphorylation	Rattus norvegicus
nutrition	calorie restriciton does not alter glycogen synthase or glycogen phosphatase activity/protein levels in young rats. Calorie restriction hinders age-related decreases in glycogen synthase activity/protein, unrelated to glycogen synthase mRNA levels, and glycogen synthase inactivation-phosphorylation	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	-	Rattus norvegicus	-
soleus	-	Rattus norvegicus	-
tibialis anterior	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)