Cloned (Comment) | Organism |
---|---|
expressed in HEK-293T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E44A | inactive | Homo sapiens |
E86A | the mutant shows about 70% activity compared to the wild type enzyme | Homo sapiens |
R105A | inactive | Homo sapiens |
R145A | the mutant shows about 130% activity compared to the wild type enzyme | Homo sapiens |
R30A | the mutant shows less than 10% activity compared to the wild type enzyme | Homo sapiens |
R72A | the mutant shows about 65% activity compared to the wild type enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione-Sepharose column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dolichyl phosphate D-mannose + glutathione-S-transferase fusion alpha-dystroglycan | - |
Homo sapiens | dolichyl phosphate + O-D-mannosyl-[glutathione-S-transferase fusion alpha-dystroglycan] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dolichyl-phosphate-mannose-protein mannosyltransferase 1 | - |
Homo sapiens |
POMT1 | - |
Homo sapiens |
POMT2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | protein O-mannosyltransferase 1 (POMT1) and its homolog, POMT2, are responsible for the catalysis of the first step in O-mannosyl glycan synthesis | Homo sapiens |