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Literature summary for 2.4.1.109 extracted from

  • Rouabhia, M.; Schaller, M.; Corbucci, C.; Vecchiarelli, A.; Prill, S.K.; Giasson, L.; Ernst, J.F.
    Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases (2005), Infect. Immun., 73, 4571-4580.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine Pmt proteins may be suitable targets for future novel classes of antifungal agents Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Candida albicans protein mannosyltransferases (Pmt proteins Pmt1p, Pmt2p, Pmt4p, Pmt5p, and Pmt6p) initiate O mannosylation of secretory proteins. Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases. The importance of individual Pmt isoforms may differ in specific host niches ?
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Organism

Organism UniProt Comment Textmining
Candida albicans
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-
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Candida albicans O74189
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Candida albicans Q59X23 putative
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Candida albicans Q5ADM9 putative
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Candida albicans Q9UVB5
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information protein mannosyltransferases (Pmt proteins Pmt1p, Pmt2p, Pmt4p, Pmt5p, and Pmt6p) initiate O mannosylation of secretory proteins. Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases. The importance of individual Pmt isoforms may differ in specific host niches Candida albicans ?
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?

Synonyms

Synonyms Comment Organism
PMT1
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Candida albicans
PMT2
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Candida albicans
PMT4
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Candida albicans
PMT5
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Candida albicans
Pmt6
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Candida albicans