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Literature summary for 2.4.1.102 extracted from

  • Higgins, E.A.; Siminovitch, K.A.; Zhuang, D.; Brockhausen, I.; Dennis, J.W.
    Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome (1991), J. Biol. Chem., 266, 6280-6290.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens patients with Wiskott-Aldrich-Syndrome show an altered enzyme activity and inversed enzyme stimulation in T cells, enzyme activity in platelets is 3fold higher compared to normal organisms ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
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Homo sapiens
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blood platelet
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Homo sapiens
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T-lymphocyte
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Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000013
-
unstimulated normal T-lymphocytes Homo sapiens
0.00004
-
EBV B-cell line from healthy individuals Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information patients with Wiskott-Aldrich-Syndrome show an altered enzyme activity and inversed enzyme stimulation in T cells, enzyme activity in platelets is 3fold higher compared to normal organisms Homo sapiens ?
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
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Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
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?