Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | - |
Oryctolagus cuniculus | |
AMP | - |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CH3Hg+ | irreversible inhibition, partial reactivation of the enzyme by GSH, but not by EDTA, about 80% inhibition at 0.03 mM | Mus musculus | |
CH3Hg+ | irreversible inhibition, partial reactivation of the enzyme by GSH, but not by EDTA | Oryctolagus cuniculus | |
Hg2+ | irreversible inhibition, partial reactivation of the enzyme by GSH, but not by EDTA, about 90% inhibition at 0.0125 mM Hg2+, 80% at 0.01 mM | Mus musculus | |
Hg2+ | irreversible inhibition, partial reactivation of the enzyme by GSH, but not by EDTA | Oryctolagus cuniculus | |
additional information | molecular and kinetic mechanisms of enzyme inhibition by mercury, overview | Mus musculus | |
additional information | molecular and kinetic mechanisms of enzyme inhibition by mercury, overview | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[(1->4)-alpha-D-glucosyl]n + phosphate | Oryctolagus cuniculus | - |
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r | |
[(1->4)-alpha-D-glucosyl]n + phosphate | Mus musculus | - |
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r | |
[(1->4)-alpha-D-glucosyl]n + phosphate | Mus musculus Swiss | - |
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9WUB3 | - |
- |
Mus musculus Swiss | Q9WUB3 | - |
- |
Oryctolagus cuniculus | P00489 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
myoblast | - |
Mus musculus | - |
myotube | - |
Mus musculus | - |
skeletal muscle | - |
Oryctolagus cuniculus | - |
skeletal muscle | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[(1->4)-alpha-D-glucosyl]n + phosphate | - |
Oryctolagus cuniculus | [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r | |
[(1->4)-alpha-D-glucosyl]n + phosphate | - |
Mus musculus | [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r | |
[(1->4)-alpha-D-glucosyl]n + phosphate | - |
Mus musculus Swiss | [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
muscle glycogen phosphorylase | - |
Oryctolagus cuniculus |
muscle glycogen phosphorylase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at, glycogen synthesis | Oryctolagus cuniculus |
37 | - |
assay at, glycogen synthesis | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at, glycogen synthesis | Oryctolagus cuniculus |
6.8 | - |
assay at, glycogen synthesis | Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00038 | - |
Hg2+ | pH 6.8, 25°C | Oryctolagus cuniculus | |
0.043 | - |
CH3Hg+ | pH 6.8, 25°C | Oryctolagus cuniculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations that impair glycogen phosphorylase activity leads to McArdle's disease which is characterized by exercise intolerance, muscle fatigue, and cramps. The irreversible inhibition of the enzyme might represent one of the mechanisms that contribute to mercury-dependent muscle toxicity | Oryctolagus cuniculus |
malfunction | mutations that impair glycogen phosphorylase activity leads to McArdle's disease which is characterized by exercise intolerance, muscle fatigue, and cramps. The irreversible inhibition of the enzyme might represent one of the mechanisms that contribute to mercury-dependent muscle toxicity | Mus musculus |
metabolism | muscle glycogen phosphorylase is the rate-limiting enzyme of glycogen breakdown in skeletal muscle | Oryctolagus cuniculus |
metabolism | muscle glycogen phosphorylase is the rate-limiting enzyme of glycogen breakdown in skeletal muscle | Mus musculus |