Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.1 extracted from

  • Xu, X.; Mathieu, C.; Boitard, S.E.; Dairou, J.; Dupret, J.M.; Agbulut, O.; Rodrigues-Lima, F.
    Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: molecular, cellular and kinetic aspects (2014), FEBS Lett., 588, 138-142.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
Oryctolagus cuniculus
AMP
-
Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CH3Hg+ irreversible inhibition, partial reactivation of the enzyme by GSH, but not by EDTA, about 80% inhibition at 0.03 mM Mus musculus
CH3Hg+ irreversible inhibition, partial reactivation of the enzyme by GSH, but not by EDTA Oryctolagus cuniculus
Hg2+ irreversible inhibition, partial reactivation of the enzyme by GSH, but not by EDTA, about 90% inhibition at 0.0125 mM Hg2+, 80% at 0.01 mM Mus musculus
Hg2+ irreversible inhibition, partial reactivation of the enzyme by GSH, but not by EDTA Oryctolagus cuniculus
additional information molecular and kinetic mechanisms of enzyme inhibition by mercury, overview Mus musculus
additional information molecular and kinetic mechanisms of enzyme inhibition by mercury, overview Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate Oryctolagus cuniculus
-
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate Mus musculus
-
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate Mus musculus Swiss
-
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WUB3
-
-
Mus musculus Swiss Q9WUB3
-
-
Oryctolagus cuniculus P00489
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
Mus musculus
-
myoblast
-
Mus musculus
-
myotube
-
Mus musculus
-
skeletal muscle
-
Oryctolagus cuniculus
-
skeletal muscle
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate
-
Oryctolagus cuniculus [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
-
Mus musculus [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
-
Mus musculus Swiss [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r

Synonyms

Synonyms Comment Organism
muscle glycogen phosphorylase
-
Oryctolagus cuniculus
muscle glycogen phosphorylase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at, glycogen synthesis Oryctolagus cuniculus
37
-
assay at, glycogen synthesis Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at, glycogen synthesis Oryctolagus cuniculus
6.8
-
assay at, glycogen synthesis Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00038
-
Hg2+ pH 6.8, 25°C Oryctolagus cuniculus
0.043
-
CH3Hg+ pH 6.8, 25°C Oryctolagus cuniculus

General Information

General Information Comment Organism
malfunction mutations that impair glycogen phosphorylase activity leads to McArdle's disease which is characterized by exercise intolerance, muscle fatigue, and cramps. The irreversible inhibition of the enzyme might represent one of the mechanisms that contribute to mercury-dependent muscle toxicity Oryctolagus cuniculus
malfunction mutations that impair glycogen phosphorylase activity leads to McArdle's disease which is characterized by exercise intolerance, muscle fatigue, and cramps. The irreversible inhibition of the enzyme might represent one of the mechanisms that contribute to mercury-dependent muscle toxicity Mus musculus
metabolism muscle glycogen phosphorylase is the rate-limiting enzyme of glycogen breakdown in skeletal muscle Oryctolagus cuniculus
metabolism muscle glycogen phosphorylase is the rate-limiting enzyme of glycogen breakdown in skeletal muscle Mus musculus