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Literature summary for 2.4.1.1 extracted from

  • Oikonomakos, N.G.; Kosmopoulou, M.; Zographos, S.E.; Leonidas, D.D.; Chrysina, E.D.; Somsak, L.; Nagy, V.; Praly, J.P.; Docsa, T.; Toth, B.; Gergely, P.
    Binding of N-acetyl-N'-beta-D-glucopyranosyl urea and N-benzoyl-N'-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies (2002), Eur. J. Biochem., 269, 1684-1696.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of glycogen phosphorylase beta-glucopyranosylidene spirothiohydantoin complex at 2.26 A resolution Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
glucopyranosylidene spirohydantoin most effective glucose analogue inhibitor for glycogen phosphorylase b Oryctolagus cuniculus
glucopyranosylidene spirothiohydantoin muscle and liver phosphorylase b, strong competitive inhibition vs. phosphate and glycogen Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Oryctolagus cuniculus
-
muscle
-
 Oryctolagus cuniculus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0023
-
 glucopyranosylidene spirothiohydantoin muscle phosphorylase b, vs. phosphate Oryctolagus cuniculus
0.0028
-
 glucopyranosylidene spirothiohydantoin muscle phosphorylase b, vs. glycogen Oryctolagus cuniculus
0.0031
-
 glucopyranosylidene spirohydantoin
-
 Oryctolagus cuniculus