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Literature summary for 2.4.1.1 extracted from
- Inhibition of alpha-glucan phosphorylase by alpha-D-glucopyranosyl fluoride (1975), J. Biochem., 78, 1191-1199.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,5-gluconolactone | strong inhibition of muscle isozyme a and b | Oryctolagus cuniculus |  |
| alpha-D-glucopyranosyl fluoride | strong inhibition of phosphorylase b, kinetics; weak inhibition | Oryctolagus cuniculus | |
| alpha-D-glucopyranosyl fluoride | weak inhibition | Solanum tuberosum | |
| UDPglucose | - |
Oryctolagus cuniculus | |
| UDPglucose | - |
Solanum tuberosum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic data | Oryctolagus cuniculus | |
| additional information | - |
additional information | kinetic data | Solanum tuberosum | |
| 0.074 | - |
AMP | phosphorylase b | Oryctolagus cuniculus | |
| 1.2 | - |
glucose 1-phosphate | - |
Solanum tuberosum | |
| 3.2 | - |
phosphate | - |
Solanum tuberosum | |
| 5.5 | - |
glucose 1-phosphate | phosphorylase b | Oryctolagus cuniculus | |
| 11 | - |
phosphate | phosphorylase b | Oryctolagus cuniculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
| Solanum tuberosum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | - |
Oryctolagus cuniculus | - |
| tuber | - |
Solanum tuberosum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycogen + glucose 1-phosphate | - |
Oryctolagus cuniculus | glycogen + phosphate | - |
r | |
| glycogen + glucose 1-phosphate | - |
Solanum tuberosum | glycogen + phosphate | - |
r | |
| [(1->4)-alpha-D-glucosyl]n + phosphate | - |
Oryctolagus cuniculus | [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r | |
| [(1->4)-alpha-D-glucosyl]n + phosphate | - |
Solanum tuberosum | [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.44 | - |
alpha-D-glucopyranosyl fluoride | phosphorylase b, at 1 mM vs. glucose 1-phosphate | Oryctolagus cuniculus | |
| 0.71 | - |
alpha-D-glucopyranosyl fluoride | phosphorylase b, at 1 mM vs. phosphate | Oryctolagus cuniculus | |
| 14 | - |
alpha-D-glucopyranosyl fluoride | at 10 mM vs. glucose 1-phosphate | Solanum tuberosum | |
| 18 | - |
alpha-D-glucopyranosyl fluoride | at 10 mM vs. phosphate | Solanum tuberosum | |
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