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Literature summary for 2.3.3.8 extracted from

  • Verschueren, K.H.G.; Blanchet, C.; Felix, J.; Dansercoer, A.; De Vos, D.; Bloch, Y.; Van Beeumen, J.; Svergun, D.; Gutsche, I.; Savvides, S.N.; Verstraete, K.
    Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle (2019), Nature, 568, 571-575 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Chlorobium limicola
-
Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
vapour diffusion crystallization Chlorobium limicola
vapour diffusion crystallization Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + citrate + CoA Chlorobium limicola
-
ADP + phosphate + acetyl-CoA + oxaloacetate
-
?
ATP + citrate + CoA Homo sapiens the enzyme links carbohydrate and lipid metabolism ADP + phosphate + acetyl-CoA + oxaloacetate
-
?

Organism

Organism UniProt Comment Textmining
Chlorobium limicola Q9AQH6
-
-
Homo sapiens P53396
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Chlorobium limicola
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue strong expression Homo sapiens
-
cholinergic neuron strong expression Homo sapiens
-
liver strong expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + citrate + CoA
-
Chlorobium limicola ADP + phosphate + acetyl-CoA + oxaloacetate
-
?
ATP + citrate + CoA
-
Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate
-
?
ATP + citrate + CoA the enzyme links carbohydrate and lipid metabolism Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate
-
?

Synonyms

Synonyms Comment Organism
ACLY
-
Chlorobium limicola
ACLY
-
Homo sapiens
ATP citrate lyase
-
Chlorobium limicola
ATP citrate lyase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
assay at Homo sapiens

General Information

General Information Comment Organism
evolution structural studies unmask a fundamental evolutionary relationship that links citrate synthase, the first enzyme of the oxidative Krebs cycle, to an ancestral tetrameric citryl-CoA lyase module that operates in the reverse Krebs cycle. This molecular transition marked a key step in the evolution of metabolism on Earth Chlorobium limicola
evolution structural studies unmask a fundamental evolutionary relationship that links citrate synthase, the first enzyme of the oxidative Krebs cycle, to an ancestral tetrameric citryl-CoA lyase module that operates in the reverse Krebs cycle. This molecular transition marked a key step in the evolution of metabolism on Earth Homo sapiens
metabolism the enzyme links carbohydrate and lipid metabolism Homo sapiens