Cloned (Comment) | Organism |
---|---|
- |
Chlorobium limicola |
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
vapour diffusion crystallization | Chlorobium limicola |
vapour diffusion crystallization | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + citrate + CoA | Chlorobium limicola | - |
ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? | |
ATP + citrate + CoA | Homo sapiens | the enzyme links carbohydrate and lipid metabolism | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlorobium limicola | Q9AQH6 | - |
- |
Homo sapiens | P53396 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Chlorobium limicola |
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | strong expression | Homo sapiens | - |
cholinergic neuron | strong expression | Homo sapiens | - |
liver | strong expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + citrate + CoA | - |
Chlorobium limicola | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? | |
ATP + citrate + CoA | - |
Homo sapiens | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? | |
ATP + citrate + CoA | the enzyme links carbohydrate and lipid metabolism | Homo sapiens | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACLY | - |
Chlorobium limicola |
ACLY | - |
Homo sapiens |
ATP citrate lyase | - |
Chlorobium limicola |
ATP citrate lyase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | structural studies unmask a fundamental evolutionary relationship that links citrate synthase, the first enzyme of the oxidative Krebs cycle, to an ancestral tetrameric citryl-CoA lyase module that operates in the reverse Krebs cycle. This molecular transition marked a key step in the evolution of metabolism on Earth | Chlorobium limicola |
evolution | structural studies unmask a fundamental evolutionary relationship that links citrate synthase, the first enzyme of the oxidative Krebs cycle, to an ancestral tetrameric citryl-CoA lyase module that operates in the reverse Krebs cycle. This molecular transition marked a key step in the evolution of metabolism on Earth | Homo sapiens |
metabolism | the enzyme links carbohydrate and lipid metabolism | Homo sapiens |