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Literature summary for 2.3.3.8 extracted from

  • Khwairakpam, A.D.; Banik, K.; Girisa, S.; Shabnam, B.; Shakibaei, M.; Fan, L.; Arfuso, F.; Monisha, J.; Wang, H.; Mao, X.; Sethi, G.; Kunnumakkara, A.B.
    The vital role of ATP citrate lyase in chronic diseases (2020), J. Mol. Med., 98, 71-95 .
    View publication on PubMed
Search for more literature for 2.3.3.8

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
480000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + citrate + CoA Homo sapiens
-
 ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53396
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + citrate + CoA
-
 Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?

Subunits

Subunits Comment Organism
homotetramer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
ACLY
-
 Homo sapiens
ATP-citrate lyase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism modulation of ACLY expression correlates with the development and progressions of various chronic diseases such as neurodegenerative diseases, cardiovascular diseases, diabetes, obesity, inflammation, and cancer. Inhibition of ACLY activity modulates the glycolysis and lipogenesis processes and stimulates normal physiological functions Homo sapiens