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Literature summary for 2.3.3.8 extracted from

  • Chen, L.Y.; Lotz, M.; Terkeltaub, R.; Liu-Bryan, R.
    Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes (2018), J. Biol. Chem., 293, 12259-12270 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.3.8

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + citrate + CoA Homo sapiens
-
 ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53396
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
acetylation human knee osteoarthritis chondrocytes exhibit increased ACLY activation (assessed by Ser-455 phosphorylation), associated with increased H3K9 and H3K27 acetylation Homo sapiens
phosphoprotein human knee osteoarthritis chondrocytes exhibit increased ACLY activation (assessed by Ser-455 phosphorylation), associated with increased H3K9 and H3K27 acetylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cartilage normal and osteoarthritis human knee chondrocytes and cartilages Homo sapiens
-
chondrocyte normal and osteoarthritis human knee chondrocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + citrate + CoA
-
 Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?

Synonyms

Synonyms Comment Organism
ACLY
-
 Homo sapiens
ATP-citrate lyase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism regulatory role of ACLY activity in chondrocyte matrix homeostasis by modulation of the nucleocytosolic pool of acetyl-CoA, which impacted on catabolic and anabolic responses via post-translational and epigenetic modifications. Increased ACLY activity in osteoarthritis chondrocytes increases nucleocytosolic acetyl-CoA, leading to increased matrix catabolism via dysregulated histone and transcription factor acetylation Homo sapiens