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Literature summary for 2.3.3.8 extracted from

  • Deb, D.K.; Chen, Y.; Sun, J.; Wang, Y.; Li, Y.C.
    ATP-citrate lyase is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells (2017), Am. J. Physiol. Renal Physiol., 313, F423-F429 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol high glucose promotes ATP-citrate lyase nuclear translocation Mus musculus 5829
-
nucleus high glucose promotes ATP-citrate lyase nuclear translocation Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + citrate + CoA Mus musculus
-
ADP + phosphate + acetyl-CoA + oxaloacetate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q91V92
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mesangial cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + citrate + CoA
-
Mus musculus ADP + phosphate + acetyl-CoA + oxaloacetate
-
?

Synonyms

Synonyms Comment Organism
ACL
-
Mus musculus
ATP-citrate lyase
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus high glucose upregulates ATP-citrate lyase expression up

General Information

General Information Comment Organism
metabolism the enzyme plays a critical role in epigenetic regulation of diabetic renal fibrosis. It is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells Mus musculus