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Literature summary for 2.3.3.8 extracted from
- ATP citrate lyase is required for normal sexual and asexual development in Gibberella zeae (2011), Fungal Genet. Biol., 48, 408-417.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | isoforms ACL1 and ACL2 mostly localize in the cytosol of hyphae and ascospores while they localize in both the nuclei and cytosol of conidia | Fusarium graminearum | 5829 | - |
| nucleus | isoforms ACL1 and ACL2 mostly localize in the cytosol of hyphae and ascospores while they localize in both the nuclei and cytosol of conidia | Fusarium graminearum | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Fusarium graminearum | - |
anamorph Fusarium graminearum | - |
| Fusarium graminearum GZ3639 | - |
anamorph Fusarium graminearum | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ascospore | - |
Fusarium graminearum | - |
| conidium | - |
Fusarium graminearum | - |
| hypha | - |
Fusarium graminearum | - |
| mycelium | - |
Fusarium graminearum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + citrate + CoA | - |
Fusarium graminearum | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? |  |
| ATP + citrate + CoA | - |
Fusarium graminearum GZ3639 | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACL | - |
Fusarium graminearum |
| ACL1 | isoform | Fusarium graminearum |
| ACL2 | isoform | Fusarium graminearum |
| adenosine triphosphate citrate lyase | - |
Fusarium graminearum |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | deletion of the enzyme results in a complete loss of self and female fertility as well as a reduction in asexual reproduction, virulence, and trichothecene production. Although lipid synthesis is not affected by enzyme deletion, histone acetylation is dramatically reduced in the enzyme deletion mutants during sexual development | Fusarium graminearum |
| physiological function | ATP citrate lyase is required for normal sexual and asexual development in Gibberella zeae | Fusarium graminearum |
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