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Literature summary for 2.3.3.8 extracted from

  • Hynes, M.; Murray, S.
    ATP-citrate lyase is required for production of cytosolic acetyl coenzyme A and development in Aspergillus nidulans (2010), Eukaryot. Cell, 9, 1039-1048.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.3.8

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 3 * 70000 + 3 * 55000 Aspergillus nidulans
70000
-
 3 * 70000 + 3 * 55000 Aspergillus nidulans

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans Q5BAJ4 and Q5BAJ5 subunits; synonym Aspergillus nidulans
-
Aspergillus nidulans 54 Q5BAJ4 and Q5BAJ5 subunits; synonym Aspergillus nidulans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + citrate + CoA
-
 Aspergillus nidulans ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?
ATP + citrate + CoA
-
 Aspergillus nidulans 54 ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?

Subunits

Subunits Comment Organism
heterohexamer 3 * 70000 + 3 * 55000 Aspergillus nidulans

Synonyms

Synonyms Comment Organism
ATP-citrate lyase
-
 Aspergillus nidulans

Expression

Organism Comment Expression
Aspergillus nidulans transcription of genes aclA and aclB is repressed by growth on acetate or ethanol down

General Information

General Information Comment Organism
malfunction loss of ATP-citrate lyase results in severe developmental effects, with the production of asexual spores (conidia) being greatly reduced and a complete absence of sexual development Aspergillus nidulans
physiological function ATP-citrate lyase is required for development in Aspergillus nidulans Aspergillus nidulans