Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | competitive against oxaloacetate | Drosophila melanogaster | |
ATP | competitive against acetyl-CoA | Drosophila melanogaster | |
additional information | tricarboxylic acid cycle intermediates | Drosophila melanogaster | |
propionyl-CoA | competitive against acetyl-CoA | Drosophila melanogaster | |
succinyl-CoA | mixed-type inhibition | Drosophila melanogaster |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0031 | - |
oxaloacetate | - |
Drosophila melanogaster | |
0.0067 | - |
acetyl-CoA | - |
Drosophila melanogaster |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
amino acid composition | Drosophila melanogaster |
48700 | - |
2 * 48700, SDS-PAGE | Drosophila melanogaster |
81000 | - |
gel filtration | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Purification (Comment) | Organism |
---|---|
antibody studies | Drosophila melanogaster |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + H2O + oxaloacetate = citrate + CoA | mechanism | Drosophila melanogaster |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
112.5 | - |
purified enzyme | Drosophila melanogaster |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + oxaloacetate + H2O | - |
Drosophila melanogaster | citrate + CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 48700, SDS-PAGE | Drosophila melanogaster |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | - |
- |
Drosophila melanogaster |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | 9 | - |
Drosophila melanogaster |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0024 | - |
propionyl-CoA | versus acetyl-CoA, competitive | Drosophila melanogaster | |
0.0225 | - |
propionyl-CoA | versus oxaloacetate, noncompetitive | Drosophila melanogaster | |
0.125 | - |
ATP | versus acetyl-CoA | Drosophila melanogaster | |
0.38 | - |
2-oxoglutarate | versus oxaloacetate, competitive | Drosophila melanogaster |