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Literature summary for 2.3.3.14 extracted from

  • Quezada, H.; Marin-Hernandez, A.; Aguilar, D.; Lopez, G.; Gallardo-Perez, J.C.; Jasso-Chavez, R.; Gonzalez, A.; Saavedra, E.; Moreno-Sanchez, R.
    The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae (2011), Mol. Microbiol., 82, 578-590.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
L-lysine isoform Lys20 is one order of magnitude less sensitive to L-lysine inhibition than Lys21 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Saccharomyces cerevisiae 5634
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae BY4741
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + 2-oxoglutarate
-
 Saccharomyces cerevisiae 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
acetyl-CoA + H2O + 2-oxoglutarate
-
 Saccharomyces cerevisiae BY4741 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
HCS
-
 Saccharomyces cerevisiae
LYS20 isoform Saccharomyces cerevisiae
LYS21 isoform Saccharomyces cerevisiae

General Information

General Information Comment Organism
metabolism the first committed step in the lysine biosynthetic pathway is catalyzed by the Lys20 and Lys21 homocitrate synthase isoforms. The Lys20 isoform exerts high control over L-lysine flux, while isoform Lys21 exerts low control over the alpha-aminoadipate-pathway flux Saccharomyces cerevisiae