Inhibitors | Comment | Organism | Structure |
---|---|---|---|
citrate | competitive versus 2-oxoglutarate; noncompetitive | Saccharomyces cerevisiae | |
CoA | noncompetitive versus acetyl-CoA | Saccharomyces cerevisiae | |
desulfo-CoA | uncompetitive | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + 2-oxoglutarate | sequential ordered kinetic mechanism for the histidine-tagged enzyme with 2-oxoglutarate binding before acetyl-CoA and CoA released before homocitrate | Saccharomyces cerevisiae | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
ir | |
acetyl-CoA + H2O + oxaloacetate | oxaloacetate is a substrate with lower affinity than 2-oxoglutarate | Saccharomyces cerevisiae | ? + CoA | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
CoA | Kis, varied substrate acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate | Saccharomyces cerevisiae | |
0.014 | - |
desulfo-CoA | Kis, varied substrate acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate | Saccharomyces cerevisiae | |
0.021 | - |
desulfo-CoA | Kii, varied substrate 2-oxoglutarate, fixed substrate: 0.031 mM acteyl-CoA | Saccharomyces cerevisiae | |
0.024 | - |
CoA | Kii, varied substrate 2-oxoglutarate, fixed substrate: 0.031 mM acetyl-CoA | Saccharomyces cerevisiae | |
0.033 | - |
CoA | Kii, varied substrate acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate | Saccharomyces cerevisiae | |
0.18 | - |
desulfo-CoA | Kii, varied substrate acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate | Saccharomyces cerevisiae | |
13.5 | - |
citrate | Kis, varied substrate is 2-oxoglutarate, fixed substrate: 0.031 mM acetyl-CoA | Saccharomyces cerevisiae | |
19 | - |
citrate | Kis, varied substrate is acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate | Saccharomyces cerevisiae | |
200 | - |
citrate | Kii, varied substrate is acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate | Saccharomyces cerevisiae |