Application | Comment | Organism |
---|---|---|
medicine | potential target for drugs against microbial pathogens due to the absence of this enzyme in mammals | Mycobacterium tuberculosis |
Cloned (Comment) | Organism |
---|---|
expressed as His-tag fusion protein in Escherichia coli BL21(DE3) | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
sitting drop vapor diffusion method | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + alpha-ketoisovalerate + H2O | Mycobacterium tuberculosis | first step of leucine biosynthesis | alpha-isopropylmalate + CoA | - |
? | |
acetyl-CoA + alpha-ketoisovalerate + H2O | Mycobacterium tuberculosis H37Rv | first step of leucine biosynthesis | alpha-isopropylmalate + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis H37Rv | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme using His-tag | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + alpha-ketoisovalerate + H2O | first step of leucine biosynthesis | Mycobacterium tuberculosis | alpha-isopropylmalate + CoA | - |
? | |
acetyl-CoA + alpha-ketoisovalerate + H2O | reaction | Mycobacterium tuberculosis | alpha-isopropylmalate + CoA | - |
? | |
acetyl-CoA + alpha-ketoisovalerate + H2O | first step of leucine biosynthesis | Mycobacterium tuberculosis H37Rv | alpha-isopropylmalate + CoA | - |
? | |
acetyl-CoA + alpha-ketoisovalerate + H2O | reaction | Mycobacterium tuberculosis H37Rv | alpha-isopropylmalate + CoA | - |
? |