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Literature summary for 2.3.3.10 extracted from

  • Liu, M.H.; Li, J.; Shen, P.; Husna, B.; Tai, E.S.; Yong, E.L.
    A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin (2008), Mol. Endocrinol., 22, 1078-1092.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the natural variant (V227A) of peroxisome proliferator-activated receptor-alpha (PPARalpha) significantly attenuates PPARalpha-mediated transactivation of the cytochrome P450 4A6 and mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) genes in the presence of fibrate ligands ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the natural variant (V227A) of peroxisome proliferator-activated receptor-alpha (PPARalpha) significantly attenuates PPARalpha-mediated transactivation of the cytochrome P450 4A6 and mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) genes in the presence of fibrate ligands Homo sapiens ?
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 ?