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Literature summary for 2.3.3.10 extracted from

  • Campobasso, N.; Patel, M.; Wilding, I.E.; Kallender, H.; Rosenberg, M.; Gwynn, M.N.
    Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism (2004), J. Biol. Chem., 279, 44883-44888.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Staphylococcus aureus

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting-drop vapour-diffusion method, crystal strcuture of full-length enzyme expressed in Escherichia coli is determined at 2.0 A resolution, crystal structure of HMG-CoA synthase with acetoacetyl-CoA is determined at 2.5 A resolution Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + acetoacetyl-CoA + H2O Staphylococcus aureus the enzyme catalyzes the first committed step in the mevalonate pathway (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + acetoacetyl-CoA + H2O
-
Staphylococcus aureus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?
acetyl-CoA + acetoacetyl-CoA + H2O the enzyme catalyzes the first committed step in the mevalonate pathway Staphylococcus aureus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?

Subunits

Subunits Comment Organism
dimer
-
Staphylococcus aureus

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl-CoA synthase
-
Staphylococcus aureus
HMG-CoS synthase
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Staphylococcus aureus