Literature summary for 2.3.3.10 extracted from

Tomoda, H.; Ohbayashi, N.; Morikawa, Y.; Kumagai, H.; Omura, S.
Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase (2004), Biochim. Biophys. Acta, 1636, 22-28.

Search for more literature for 2.3.3.10

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Cricetinae

Inhibitors

Inhibitors	Comment	Organism	Structure
hymeglusin	IC50: 0.00032 mM, inhibitor binds to the thiol residue of Cys	Cricetinae
hymeglusin	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-
cytosol	-	Cricetinae	5829	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
53000	-	2 * 53000, SDS-PAGE	Cricetinae

Organism

Organism	UniProt	Comment	Textmining
Cricetinae	-	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant	Cricetinae

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Subunits

Subunits	Comment	Organism
dimer	2 * 53000, SDS-PAGE	Cricetinae

Synonyms

Synonyms	Comment	Organism
3-hydroxy-3-methylglutaryl coenzyme A synthase	-	Rattus norvegicus
3-hydroxy-3-methylglutaryl coenzyme A synthase	-	Cricetinae
HMG-CoA synthase	-	Rattus norvegicus
HMG-CoA synthase	-	Cricetinae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00032	-	IC50: 0.00032 mM, inhibitor binds to the thiol residue of Cys	Cricetinae	hymeglusin

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Release 2023.1 (January 2023)