Application | Comment | Organism |
---|---|---|
medicine | deficiency of the mitochondrial isoform correlates with human metabolic disease, cytosolic isoform is potentially useful target for drugs aimed at lowering cholesterol levels | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cDNA subcloned and expressed from a T7-based vector in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetoacetyl-CoA | - |
Gallus gallus | |
acetoacetyl-CoA | - |
Homo sapiens | |
acetoacetyl-CoA | - |
Rattus norvegicus | |
L-659,699 | potent inhibitor of the recombinant enzyme | Homo sapiens | |
L-659,699 | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.029 | - |
acetyl-CoA | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Gallus gallus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Rattus norvegicus | 5737 | - |
cytosol | - |
Gallus gallus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
mitochondrion | - |
Gallus gallus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
120000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | Gallus gallus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Cricetulus griseus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Homo sapiens | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Rattus norvegicus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
chinese hamster | - |
Gallus gallus | - |
chicken | - |
Homo sapiens | - |
human | - |
Rattus norvegicus | - |
rat | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
adrenal gland | - |
Rattus norvegicus | - |
fetus | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
liver | - |
Gallus gallus | - |
liver | - |
Rattus norvegicus | - |
ovary | - |
Cricetulus griseus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.76 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Cricetulus griseus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Rattus norvegicus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Gallus gallus |
dimer | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000537 | - |
L-659,699 | - |
Homo sapiens | |
0.012 | - |
acetoacetyl-CoA | - |
Homo sapiens |