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Literature summary for 2.3.3.10 extracted from

  • Menahan, L.A.; Hron, W.T.; Hinkelman, D.G.; Miziorko, H.M.
    Interrelationships between 3-hydroxy-3-methylglutaryl-CoA synthase, aetoacetyl-CoA and ketogenesis (1981), Eur. J. Biochem., 119, 287-296.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetoacetyl-CoA substrate inhibition Gallus gallus
acetoacetyl-CoA substrate inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00035
-
acetoacetyl-CoA
-
Gallus gallus
0.009
-
acetyl-CoA absence of acetoacetyl-CoA, hydrolysis reaction Rattus norvegicus
0.2
-
acetyl-CoA 0.01 M acetoacetyl-CoA Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Gallus gallus 5737
-
cytoplasm
-
Rattus norvegicus 5737
-
mitochondrion
-
Gallus gallus 5739
-
mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + acetoacetyl-CoA + H2O Rattus norvegicus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?
acetyl-CoA + acetoacetyl-CoA + H2O Gallus gallus enzyme involved in ketone body production, control of hepatic fatty acid oxidation, potential control point for ketogenesis (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?
acetyl-CoA + acetoacetyl-CoA + H2O Rattus norvegicus Sprague-Dawley
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
chicken
-
Gallus gallus
-
avian
-
Rattus norvegicus
-
rat
-
Rattus norvegicus
-
Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
mitochondrial form Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-
liver
-
Rattus norvegicus
-
myocardium
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + acetoacetyl-CoA + H2O
-
Gallus gallus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?
acetyl-CoA + acetoacetyl-CoA + H2O
-
Rattus norvegicus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?
acetyl-CoA + acetoacetyl-CoA + H2O enzyme involved in ketone body production, control of hepatic fatty acid oxidation, potential control point for ketogenesis Gallus gallus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?
acetyl-CoA + acetoacetyl-CoA + H2O
-
Rattus norvegicus Sprague-Dawley (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.4
-
-
Gallus gallus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.006 0.01 acetoacetyl-CoA
-
Gallus gallus