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Literature summary for 2.3.3.1 extracted from

  • Crumbley, C.; Wang, Y.; Banerjee, S.; Burris, T.P.
    Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor alpha (RORalpha) (2012), PLoS ONE, 7, e33804.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.3.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Hep-G2 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + oxaloacetate
-
 Mus musculus citrate + CoA
-
 ?
acetyl-CoA + H2O + oxaloacetate
-
 Homo sapiens citrate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
citrate synthase
-
 Mus musculus
citrate synthase
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus the mRNA expression of citrate synthase in liver is reduced by 42% in the staggerer mice (which possess a nonfunctional retinoic acid receptor-related orphan receptor alpha protein) relative to the wild type mice down
Homo sapiens overexpression of retinoic acid receptor-related orphan receptor alpha (5fold), leads to a 94% increase in citrate synthase mRNA levels and enzyme activity in Hep-G2 cells up

General Information

General Information Comment Organism
metabolism citrate synthase is a key enzyme of the citric acid cycle that provides energy for cellular function. Additionally, the enzyme plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis Mus musculus
metabolism citrate synthase is a key enzyme of the citric acid cycle that provides energy for cellular function. Additionally, the enzyme plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis Homo sapiens
physiological function the citrate synthase gene is a direct retinoic acid receptor-related orphan receptor alpha target and one mechanism by which retinoic acid receptor-related orphan receptor alpha regulates lipid metabolism is via regulation of citrate synthase expression Mus musculus
physiological function the citrate synthase gene is a direct retinoic acid receptor-related orphan receptor alpha target and one mechanism by which retinoic acid receptor-related orphan receptor alpha regulates lipid metabolism is via regulation of citrate synthase expression Homo sapiens