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Literature summary for 2.3.2.B11 extracted from

  • Ziegenhagen, R.; Jennissen, H.P.
    Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase (1988), Biol. Chem. Hoppe-Seyler, 369, 1317-1324.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0081
-
 Calmodulin pH 8.0, 37°C Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Oryctolagus cuniculus
Ca2+ optimal concentration: 0.1 mM Oryctolagus cuniculus
Ca2+ Km: 0.005-0.010 mM Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n ATP + calmodulin + n ubiquitin Oryctolagus cuniculus Ca2+-dependent ubiquitination only of free calmodulin may provide an efficient scavenging mechanism (with subsequent breakdown) for all free calmodulin in excess of that amount which can be found by the calmodulin-binding proteins in the cell ?
-
 ?
[RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine Oryctolagus cuniculus specific for Ca2+-calmodulin from vertebrates, at least 3 ubiquitin molecules can be coupled to lysine residues in calmodulin [RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
reticulocyte
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
n ATP + calmodulin + n ubiquitin Ca2+-dependent ubiquitination only of free calmodulin may provide an efficient scavenging mechanism (with subsequent breakdown) for all free calmodulin in excess of that amount which can be found by the calmodulin-binding proteins in the cell Oryctolagus cuniculus ?
-
 ?
[RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine specific for Ca2+-calmodulin from vertebrates, at least 3 ubiquitin molecules can be coupled to lysine residues in calmodulin Oryctolagus cuniculus [RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine
-
 ?
[RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine mammalian calmodulin containing trimethyllysine 115, only the free form of calmodulin can be ubiquitinated. Neither calmodulin bound to phosphorylase kinase as an integral subunit (delta-subunit) not that bound as a peripheral subunit (delta-subunit) is ubiquitinated Oryctolagus cuniculus [RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine
-
 ?