Application | Comment | Organism |
---|---|---|
medicine | the inhibition of ATE1 activity may provide an approach for the treatment of cardiac hypertrophy in humans | Rattus norvegicus |
Cloned (Comment) | Organism |
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gene ATE1, quantitative real-time-PCR expression analysis in H9C2 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | for the generation of ATE1 knockdown hypertrophied rats, ATE1 siRNA is encapsulated in stearic acid-modified carboxy methyl chitosan (CMC) conjugated to a cardiomyocyte-targeting peptide. Cardiac function is improved in terms of left ventricular diastolic dysfunction (LVDd) and fractional shortening (%FS) in the ligated + ATE1-siRNA as compared to the Ligated + NS-siRNA when examined by M-Mode echocardiography. Cardiac ATE1 deficiency restores cardiac dysfunction after right renal artery ligation. ATE1 knockdown H9C2 cells | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac muscle fiber | - |
Rattus norvegicus | - |
H9c2 cell | quantitative real-time-PCR expression analysis of ATE1 | Rattus norvegicus | - |
heart | enhanced ATE1 expression in hypertrophied heart samples, quantitative real-time-PCR expression analysis | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
Ate1 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | ATE1 expression is upregulated by hypertrophic stimuli, increase in ATE1 expression upon hypertrophic stress | up |
General Information | Comment | Organism |
---|---|---|
evolution | arginyltransferase (ATE1) is an evolutionary conserved enzyme | Rattus norvegicus |
malfunction | knockdown of arginyltransferase ATE1 attenuates cardiac hypertrophy and fibrosis in vitro and in vivo through the TAK1-JNK1/2 pathway. The cardioprotective role of ATE1 silencing is mediated by the interruption of TAK1 activity-dependent JNK1/2 signaling pathway. The MAPK signaling cascade is one of the signaling pathways involved in cardiac hypertrophy. ATE1 knockdown in presence of cardiac stress performs a cardioprotective action. Cardiac ATE1 deficiency restores cardiac dysfunction after right renal artery ligation. Phenotype, overview | Rattus norvegicus |
physiological function | arginyltransferase ATE1 can modulate the hypertrophic growth of myocytes induced by Ang II. Physiological importance of ATE1 in higher eukaryotes | Rattus norvegicus |