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Literature summary for 2.3.2.8 extracted from

  • Brower, C.S.; Varshavsky, A.
    Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations (2009), PLoS ONE, 4, e7757.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
mouse genomic DNA encoding Ate1 is isolated from a BAC library, Ate1-deficient mouse strains are constructed Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
determined by SDS-PAGE and Western Blot analysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginyl-tRNAArg + protein Mus musculus
-
tRNAArg + L-arginyl-[protein]
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z2A5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brown adipose tissue
-
Mus musculus
-
heart
-
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
muscle
-
Mus musculus
-
white adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginyl-tRNAArg + protein
-
Mus musculus tRNAArg + L-arginyl-[protein]
-
?
L-arginyl-tRNAArg + Rgs16 regulator of G protein
-
Mus musculus tRNAArg + L-arginyl-[Rgs16 regulator of G protein]
-
?
L-arginyl-tRNAArg + Rgs4 regulator of G protein
-
Mus musculus tRNAArg + L-arginyl-[Rgs4 regulator of G protein]
-
?
L-arginyl-tRNAArg + Rgs5 regulator of G protein
-
Mus musculus tRNAArg + L-arginyl-[Rgs5 regulator of G protein]
-
?

Synonyms

Synonyms Comment Organism
Arg-tRNA-protein transferase
-
Mus musculus
arginyl-tRNA-protein transferase 1
-
Mus musculus
arginyltransferase
-
Mus musculus
Ate1
-
Mus musculus
R-transferase
-
Mus musculus

General Information

General Information Comment Organism
physiological function N-terminal arginylation of intracellular proteins by Arg-tRNA-protein transferase is a part of the N-end rule pathway of protein degradation Mus musculus