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Literature summary for 2.3.2.8 extracted from

  • Ciechanover, A.; Ferber, S.; Ganoth, D.; Elias, S.; Avram, H.; Arfin, S.
    Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway (1988), J. Biol. Chem., 263, 11155-11167.
    View publication on PubMed
Search for more literature for 2.3.2.8

Inhibitors

Inhibitors Comment Organism Structure
Di- and tripeptides most potent inhibitor is Glu-Val-Phe, inhibits transfer of arginine to acceptor proteins Oryctolagus cuniculus
L-Glu-L-Val-L-Phe
-
 Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
360000
-
 multienzyme complex of several molecules of arginyl-tRNA synthetase and arginyl-tRNA-protein transferase, gel filtration Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginyl-tRNAArg + acceptor protein Oryctolagus cuniculus possibly involved in degradation of proteins with acidic NH2-termini tRNAArg + L-arginyl-[acceptor protein]
-
 ?
L-arginyl-tRNAArg + acceptor protein Oryctolagus cuniculus catalyzes post-translational ribosome-independent modification of certain acceptor proteins tRNAArg + L-arginyl-[acceptor protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
reticulocyte
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0047
-
-
 Oryctolagus cuniculus
1.3
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginyl-tRNAArg + acceptor protein
-
 Oryctolagus cuniculus tRNAArg + L-arginyl-[acceptor protein]
-
 ?
L-arginyl-tRNAArg + acceptor protein possibly involved in degradation of proteins with acidic NH2-termini Oryctolagus cuniculus tRNAArg + L-arginyl-[acceptor protein]
-
 ?
L-arginyl-tRNAArg + acceptor protein catalyzes post-translational ribosome-independent modification of certain acceptor proteins Oryctolagus cuniculus tRNAArg + L-arginyl-[acceptor protein]
-
 ?
L-arginyl-tRNAArg + albumin from bovine serum Oryctolagus cuniculus tRNAArg + L-arginyl-albumin
-
 ?
L-arginyl-tRNAArg + alpha lactalbumin bovine Oryctolagus cuniculus tRNAArg + L-arginyl-[lactalbumin]
-
 ?
L-arginyl-tRNAArg + immunoglobulin kappa-light chain of immunoglobulin Oryctolagus cuniculus tRNAArg + L-arginyl-[immunoglobulin]
-
 ?
L-arginyl-tRNAArg + trypsin inhibitor from soybean Oryctolagus cuniculus tRNAArg + L-arginyl-[trypsin inhibitor]
-
 ?

Subunits

Subunits Comment Organism
More multienzyme complex of several molecules of arginyl-tRNA synthetase and arginyl-tRNA-protein transferase Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.02
-
 Glu-Val-Phe
-
 Oryctolagus cuniculus